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Objective: To preliminarily investigate the infection status of the human immunodeficiency virus (HIV), hepatitis B virus (HBV), treponema pallidum and hepatitis C virus (HCV) in pregnant women in Hainan Province, so as to provide evidence for effective prevention and treatment of mother-to-child transmission. Methods: From October 2017 to July 2019, 8 970 pregnant women who came to our hospital for outpatient examination during pregnancy were tested for HIV, treponema pallidum and HCV antibody by ELISA and tested for rapid detection of HBV surface antigen in serum by gold immune-chromatographic assay. Results: The positive rate of HIV, treponema pallidum and HCV antibody was 0.01% (1/8 970), 0.65% (58/8 970) and 0.11% (10/8 970), respectively, and the positive rate of HBV surface antigen was 11.13% (998/8 970). Conclusions: Among the 8 970 pregnant women, the HBV infection rate was the highest (11.13%), significantly higher than that of the other three infectious diseases, followed by the treponema pallidum and HCV positive rate, and the HIV positive rate was the lowest. Therefore, it is suggested that pregnant women should strengthen prenatal examinations to improve the awareness of prevention of infectious diseases, which is conducive to prepotency. Meanwhile, it is urgent to improve the screening and treatment for epidemic infectious disease in Haikou.
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Floating-Harbor syndrome (FHS) is an autosomal dominant genetic disease caused by SRCAP mutation. This article reports the clinical features of a boy with FHS. The boy, aged 11 years and 7 months, attended the hospital due to short stature for more than 8 years and had the clinical manifestations of unusual facial features (triangularly shaped face, thin lips and long eyelashes), skeletal dysplasia (curvature finger), expressive language disorder, and retardation of bone age. Genetic detection revealed a novel heterozygous mutation, c.7330 C>T(p.R2444X), in the SRCAP gene. The boy was diagnosed with FHS based on these clinical manifestations and gene detection results. FHS is rare in clinical practice, which may lead to missed diagnosis and misdiagnosis, and gene detection may help with the clinical diagnosis of FHS in children.
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Child , Humans , Male , Abnormalities, Multiple , Adenosine Triphosphatases , Craniofacial Abnormalities , Growth Disorders , Heart Septal Defects, VentricularABSTRACT
Objective:To investigate the effect of bone marrow mesenchymal stem cells transplantation on the cognitive function in hippocampus after traumatic brain injury in rats.Methods: BMSCs were isolated and cultured from male 3-week-old SD rats in vitro.60 female SD rats were randomly divided into 3 groups(n=20),control group,model group,BMSCs treatment group.After the es-tablishment of brain trauma model of the model 1,7,14,28 d,BMSCs treatment group was given BMSCs(1×106ml-1)intervention.In addition,20 rats were tested by water maze,and each group was divided into four points:6,7,8 9 d after injury.The morphological changes of brain tissue was detected by HE staining;the water content of brain tissue was detected by dry wet method;Morris detection method,detection of spatial learning and memory ability in rats;nerve motor function score, neural function analysis detection;field test,detection of spatial learning and memory ability in rats.Results: The morphological changes of brain were observed by HE staining;the water content of brain tissue was detected by wet and dry gravity;the water maze test was conducted to examine the spatial learning ability,the motor function score,and the field experiment.The results of wet and dry gravity test showed that compared with the control group,the model group was significantly higher than the control group(P< 0.05),the water content of the treatment group at each time was significantly lower than the model group;the results of water maze test showed that the latency of safe island was significantly increased in the model group on the eighth and ninth day after injury,compared with the control group,and the difference was statistically significant(P<0.05).In the treatment group,the safe island latency was significantly shorter in the eighth day and ninth day after injury than in the control group;the neurological score results showed that compared with control group,model group,rats in the hind limb grasping reflex,vibrissae evoked forelimb positioning and lateral pad step tests were not normal performance,resulting in functional score decreased with statistical significance(P<0.05).The functional scores of the treatment group and the model group were significantly higher than those of the model group.Conclusion:Through the behavioral related tests,the data show that BMSCs can restore the neurological function to a certain extent after traumatic brain injury in rats.
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Objective To investigate the clinical efficacy of superficial needling therapy for early ankylosing spondylitis and its effect on tumor necrosis factor-α (TNF-α), interleukin-1 (IL-1) and interleukin-6 (IL-6).Methods Eighty patients with early ankylosing spondylitis meeting the inclusion criteria were randomly allocated to treatment and control groups using random number card method with the ratio of 1:1, 40 cases each. The treatment group received superficial needling therapy alone and the control group, conventional treatment with celecoxib capsules, methotrexate tablets and sulfasalazine enteric-coated tablets. Treatment was given for a total of 24 weeks. Bath AS Disease Activity Index (BASDAI), Bath AS Functional Index (BASFI), lumbago, TCM syndrome score, TNF-α, IL-1 and IL-6 were observed in the two groups before and after treatment.Results The BASDAI, BASFI, lumbago, TCM syndrome score, TNF-α, IL-1 and IL-6 improved in the two groups after treatment compared with those before the treatment (P<0.05). The BASDAI, BASFI, lumbago, TCM syndrome score, TNF-α, IL-1 and IL-6 in the treatment group superior to those in the control group after the treatment (P<0.05).Conclusions Superficial needling therapy can relieve the clinical symptoms in patients with early ankylosing spondylitis and improve spinal joint function with good safety. Its mechanism may be related to reducing inflammatory cytokines TNF-α, IL-1 and IL-6.
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Objective To investigate the clinical efficacy of superficial needling therapy for early ankylosing spondylitis and its effect on tumor necrosis factor-α (TNF-α), interleukin-1 (IL-1) and interleukin-6 (IL-6).Methods Eighty patients with early ankylosing spondylitis meeting the inclusion criteria were randomly allocated to treatment and control groups using random number card method with the ratio of 1:1, 40 cases each. The treatment group received superficial needling therapy alone and the control group, conventional treatment with celecoxib capsules, methotrexate tablets and sulfasalazine enteric-coated tablets. Treatment was given for a total of 24 weeks. Bath AS Disease Activity Index (BASDAI), Bath AS Functional Index (BASFI), lumbago, TCM syndrome score, TNF-α, IL-1 and IL-6 were observed in the two groups before and after treatment.Results The BASDAI, BASFI, lumbago, TCM syndrome score, TNF-α, IL-1 and IL-6 improved in the two groups after treatment compared with those before the treatment (P<0.05). The BASDAI, BASFI, lumbago, TCM syndrome score, TNF-α, IL-1 and IL-6 in the treatment group superior to those in the control group after the treatment (P<0.05).Conclusions Superficial needling therapy can relieve the clinical symptoms in patients with early ankylosing spondylitis and improve spinal joint function with good safety. Its mechanism may be related to reducing inflammatory cytokines TNF-α, IL-1 and IL-6.